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Int J Environ Res Public Health. 2009 Nov;6(11):2752-61. doi: 10.3390/ijerph6112752. Epub 2009 Nov 3.

Is there a link between wheezing in early childhood and adverse birth outcomes? A systematic review.

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  • 1University Hospital of Heraklion, Crete, Greece.


We aimed to provide a summary of the existing published knowledge on the association between adverse birth outcomes and the development of wheezing during the first two years of life. We carried out a systematic review of epidemiological studies within the MEDLINE database. Epidemiological studies on human subjects, published in English, were included in the review. A comprehensive literature search yielded 72 studies for further consideration. Following the application of the eligibility criteria we identified nine studies. A positive association and an excess risk of wheezing during the first two years of life were revealed for adverse birth outcomes.


adverse birth outcomes; asthma; low birth weight; preterm; respiratory disorder; wheezing

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