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Clin Calcium. 2010 Jan;20(1):83-8. doi: CliCa10018388.

[Calcium antagonists: current and future applications based on new evidence. Neuroprotective effect of calcium antagonists].

[Article in Japanese]

Author information

1
Department of Neurology, Faculty of Medicine, Saitama Medical University, Japan.

Abstract

Voltage-dependent Ca(2+) channels have been divided into at least 5 types (L-, N-, T-, P-, and Q-type). L/N-type Ca(2+) channel blocker cilnidipine could reduce the size of cerebral infarction in the rat focal brain ischemia. L-type Ca(2+) channel blocker amlodipine reduced cerebral edema and inhibit neuronal cell death. N-type Ca(2+) channel blocker omega-conotoxin reduce the size of cerebral infarction and inhibit delayed neuronal cell death in hippocampal CA1 area. It is suggested that calcium antagonist has neuroprotective effect.

PMID:
20048438
DOI:
CliCa10018388
[Indexed for MEDLINE]

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