Although the influence of neural activity on immune and inflammatory pathways is undisputed, details of how neurotransmitters modulate signaling by cytokine and antigen receptors remain sketchy. New findings on the influence of the serotonin receptor subtype 2A (5-HT2A) and receptors for Tumor Necrosis Factor (TNF) suggest that in some cases there may be direct interactions between neurotransmitter and cytokine receptor signaling. These findings have implications for the many psychiatric patients on medications that modulate serotonin signaling and suggest that neurotransmitter receptors should not be ignored as candidate targets for immunoregulation.