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Am J Psychiatry. 2010 Apr;167(4):444-50. doi: 10.1176/appi.ajp.2009.09050723. Epub 2010 Jan 4.

Suppression of the P50 evoked response and neuregulin 1-induced AKT phosphorylation in first-episode schizophrenia.

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1
Department of Psychiatry and Psychotherapy, Semmelweis University, Hungary. szkeri@phys.szote.u-szeged.hu

Abstract

OBJECTIVE:

Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes.

METHOD:

The P50 evoked potential was recorded in 30 first-episode, never-medicated patients with schizophrenia and in 30 healthy comparison volunteers. Neuregulin 1-induced activation of the phosphoinositide 3'-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta system was characterized by the measurement of the phosphorylated AKT to total AKT ratio in peripheral B lymphoblasts.

RESULTS:

Relative to comparison subjects, patients with first-episode schizophrenia displayed diminished P50 suppression and decreased neuregulin 1-induced AKT phosphorylation. There was a significant relationship between P50 suppression and AKT phosphorylation.

CONCLUSION:

Decreased neuregulin 1-induced activation of the PI3K/AKT system is associated with impaired sensory gating in first-episode schizophrenia.

PMID:
20048019
DOI:
10.1176/appi.ajp.2009.09050723
[Indexed for MEDLINE]
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