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Diabetes Res Clin Pract. 2010 Mar;87(3):e26-8. doi: 10.1016/j.diabres.2009.12.008. Epub 2010 Jan 4.

Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy.

Author information

1
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Chiba, Japan.

Abstract

SP1 mRNA was highly expressed in the epiretinal membranes of proliferative diabetic retinopathy (PDR), and the SP1 protein was mainly co-localized with vascular endothelial growth factor. SP1 might play an important role in the angiogenesis of PDR by regulating the promoter activity and expression of genes encoding angiogenesis-related factors.

PMID:
20047772
DOI:
10.1016/j.diabres.2009.12.008
[Indexed for MEDLINE]

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