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J Infect Dis. 2010 Feb 1;201(3):336-40. doi: 10.1086/649899.

HIV infection and aging independently affect brain function as measured by functional magnetic resonance imaging.

Author information

1
Department of Neurology, Washington University, St Louis, Missouri, USA. bances@wustl.edu

Abstract

We investigated the interactions between human immunodeficiency virus (HIV) infection and aging and their effects on brain function demands by means of functional magnetic resonance imaging (fMRI). A multiple-regression model was used to study the association and interaction between fMRI measures, HIV serostatus, and age for 26 HIV-infected subjects and 25 seronegative subjects. Although HIV serostatus and age independently affected fMRI measures, no interaction occurred. Functional brain demands in HIV-positive subjects were equivalent to those of HIV-negative subjects who were 15-20 years older. Frailty parallels between HIV infection and aging could result from continued immunological challenges depleting resources and triggering increased metabolic demands. In the future, fMRI could be a noninvasive biomarker to assess HIV infection in the brain.

PMID:
20047503
PMCID:
PMC2804778
DOI:
10.1086/649899
[Indexed for MEDLINE]
Free PMC Article

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