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Clin Infect Dis. 2010 Feb 1;50(3):387-90. doi: 10.1086/649874.

Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid.

Author information

1
Department of Virology, University Medical Center Utrecht, G04.614 Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.

Abstract

We report the selection of enfuvirtide-resistant human immunodeficiency virus type 1 in cerebrospinal fluid, resulting in subsequent loss of viral suppression in the plasma. This case report emphasizes the potential danger of low-level penetration of entry inhibitors into the central nervous system.

PMID:
20047481
DOI:
10.1086/649874
[Indexed for MEDLINE]

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