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Fungal Genet Biol. 2010 Apr;47(4):297-309. doi: 10.1016/j.fgb.2009.12.012. Epub 2010 Jan 4.

PARP is involved in replicative aging in Neurospora crassa.

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1
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, United States. gok1@psu.edu <gok1@psu.edu>

Abstract

Modification of proteins by the addition of poly(ADP-ribose) is carried out by poly(ADP-ribose) polymerases (PARPs). PARPs have been implicated in a wide range of biological processes in eukaryotes, but no universal function has been established. A study of the Aspergillus nidulans PARP ortholog (PrpA) revealed that the protein is essential and involved in DNA repair, reminiscent of findings using mammalian systems. We found that a Neurospora PARP orthologue (NPO) is dispensable for cell survival, DNA repair and epigenetic silencing but that replicative aging of mycelia is accelerated in an npo mutant strain. We propose that PARPs may control aging as proposed for Sirtuins, which also consume NAD+ and function either as mono(ADP-ribose) transferases or protein deacetylases. PARPs may regulate aging by impacting NAD+/NAM availability, thereby influencing Sirtuin activity, or they may function in alternative NAD+-dependent or NAD+-independent aging pathways.

PMID:
20045739
PMCID:
PMC2841980
DOI:
10.1016/j.fgb.2009.12.012
[Indexed for MEDLINE]
Free PMC Article
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