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J Cyst Fibros. 2010 Mar;9(2):110-6. doi: 10.1016/j.jcf.2009.11.010. Epub 2009 Dec 31.

Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis.

Author information

  • 1Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, 6th Floor, Baltimore, MD 21205, United States. crsudfeld@gmail.com

Abstract

BACKGROUND:

Filamentous fungi are frequently recovered from respiratory cultures of individuals with CF.

METHODS:

A CF cohort database was utilized to determine filamentous fungal prevalence and risk factors.

RESULTS:

The prevalence of filamentous fungal isolation increased from 2.0% in 1997 to 28.7% in 2007. The odds of isolating filamentous fungi during a quarter was greater in CF adults [p<0.001], during chronic oral antibiotic use [p=0.002] and increased with each 10% drop in FEV(1) percent predicted [p=0.005], while inhaled corticosteroids surprisingly decreased the likelihood [p=0.012]. The direction of these effects persisted after excluding individuals with ABPA. A sub-analysis determined older age [p=0.019] and use of inhaled antibiotics [p=0.011] were independent risk factors for onset of fungal colonization.

CONCLUSIONS:

This study suggests that isolation of filamentous fungi in CF at JHH has increased and risk factors include older age, decreased lung function, and chronic oral antibiotics.

PMID:
20045384
PMCID:
PMC4113956
DOI:
10.1016/j.jcf.2009.11.010
[PubMed - indexed for MEDLINE]
Free PMC Article
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