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J Neurol Sci. 2010 Mar 15;290(1-2):146-7. doi: 10.1016/j.jns.2009.12.007. Epub 2009 Dec 31.

Excessive daytime somnolence in spinocerebellar ataxia type 1.

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Melbourne Sleep Disorders Centre, East Melbourne, Victoria, 3002, Australia.


Autosomal dominant spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders which result in dysfunction of the neuronal systems of the spinal cord, brainstem, and cerebellum. The manifestations of daytime somnolence and abnormal sleep behavior have been described in SCA type 3 (SCA3) and SCA type 6 (SCA6), but as yet have not been described in SCA type 1 (SCA1). We report two cases of sleep disturbance, fatigue and excessive daytime somnolence in individuals with SCA1 and their progress through several therapies. These case studies are unique as they describe excessive daytime somnolence and sleep abnormalities in SCA1.

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