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Maturitas. 2010 Feb;65(2):131-7. doi: 10.1016/j.maturitas.2009.12.014. Epub 2009 Dec 30.

Midlife predictors of Alzheimer's disease.

Author information

1
William S. Middleton Memorial Veterans Hospital, Geriatric Research Educational and Clinical Center, Madison, WI, USA. bbb@medicine.wisc.edu

Abstract

Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes, and family history of AD. Several risk factors for AD are endogenous; however, accumulating evidence implicates modifiable risk factors in the pathogenesis of AD. Although the continued task of identifying new genes will be critical to learning more about the disease, several research findings suggest that potentially alterable environmental factors influence genetic contributions, providing targets for disease prevention and treatment. Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife.

PMID:
20044221
PMCID:
PMC2895971
DOI:
10.1016/j.maturitas.2009.12.014
[Indexed for MEDLINE]
Free PMC Article
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