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FEBS Lett. 2010 Apr 2;584(7):1393-8. doi: 10.1016/j.febslet.2009.12.047. Epub 2009 Dec 28.

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems.

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1
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, UK.

Abstract

The ubiquitin proteasome system (UPS) and macroautophagy (hereafter called autophagy) were, for a long time, regarded as independent degradative pathways with few or no points of interaction. This view started to change recently, in the light of findings that have suggested that ubiquitylation can target substrates for degradation via both pathways. Moreover, perturbations in the flux through either pathway have been reported to affect the activity of the other system, and a number of mechanisms have been proposed to rationalise the link between the UPS and autophagy. Here we critically review these findings and outline some outstanding issues that still await clarification.

PMID:
20040365
DOI:
10.1016/j.febslet.2009.12.047
[Indexed for MEDLINE]
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