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J Am Chem Soc. 2010 Jan 27;132(3):1018-22. doi: 10.1021/ja9061272.

Array-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.

Author information

1
Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.

Abstract

A family of conjugated fluorescent polymers was used to create an array for cell sensing. Fluorescent conjugated polymers with pendant charged residues provided multivalent interactions with cell membranes, allowing the detection of subtle differences between different cell types on the basis of cell surface features. Highly reproducible characteristic patterns were obtained from different cell types as well as from isogenic cell lines, enabling the identification of the cell type as well differentiating between normal, cancerous, and metastatic isogenic cell types with high accuracy.

PMID:
20039629
PMCID:
PMC2810251
DOI:
10.1021/ja9061272
[Indexed for MEDLINE]
Free PMC Article

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