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J Interferon Cytokine Res. 2010 Apr;30(4):219-22. doi: 10.1089/jir.2009.0042.

Rare human IFNG variants.

Author information

1
Bernhard Nocht Institute for Tropical Medicine, Department of Molecular Medicine, Hamburg, Germany.

Abstract

After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler((R))-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.

PMID:
20038203
DOI:
10.1089/jir.2009.0042
[Indexed for MEDLINE]

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