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Nano Lett. 2010 Feb 10;10(2):484-9. doi: 10.1021/nl903264h.

Gd(III)-nanodiamond conjugates for MRI contrast enhancement.

Author information

1
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.

Abstract

A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T(1) of water protons with a per-Gd(III) relaxivity of 58.82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported.

PMID:
20038088
PMCID:
PMC2829273
DOI:
10.1021/nl903264h
[Indexed for MEDLINE]
Free PMC Article

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