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Curr Opin Genet Dev. 2010 Feb;20(1):65-71. doi: 10.1016/j.gde.2009.11.004. Epub 2009 Dec 25.

Inflammation and oncogenesis: a vicious connection.

Author information

1
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Abstract

Epidemiological and experimental data suggest a close connection between inflammation and tumorigenesis. Solid tumors are typically infiltrated with immune cells and inflammation impacts most, if not all, stages of tumorigenesis. Molecular and cellular pathways, which connect inflammation and cancer, have emerged as attractive targets for prevention and therapy. In this review we discuss general mechanisms and concepts of cancer promoting inflammation.

PMID:
20036794
PMCID:
PMC2821983
DOI:
10.1016/j.gde.2009.11.004
[Indexed for MEDLINE]
Free PMC Article

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