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Langmuir. 2010 May 4;26(9):6529-34. doi: 10.1021/la904066y.

Poly(ethylene glycol) and hydroxy functionalized alkane phosphate mixed self-assembled monolayers to control nonspecific adsorption of proteins on titanium oxide surfaces.

Author information

1
BioMatLab, Bioengineering Department, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. sabrina.bozzini@polimi.it

Abstract

The spontaneous formation of alkane phosphate self-assembled monolayers (SAMs) on titanium oxide was chosen as a tool to tailor the surface physicochemical properties in terms of nonspecific adsorption of proteins. For this aim, poly(ethylene glycol)-modified (PEG) alkane phosphate was codeposited with OH-terminated alkane phosphates. X-ray photoelectron spectroscopy and ellipsometry of the resulting mixed SAMs indicate that the PEG density can be controlled by varying the mole fraction of PEG-terminated phosphates in the solutions used during the deposition process, leading to surfaces with different degrees of protein resistance.

PMID:
20035571
DOI:
10.1021/la904066y
[Indexed for MEDLINE]
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