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Zhong Yao Cai. 2009 Sep;32(9):1407-10.

[Primary study on mechanism of baicalin on the Th1/Th2 response in murine model of asthma].

[Article in Chinese]

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College of Herbal Pharmacy, Jinan University, Guangzhou 510632, China.



To study the mechanism of baicalin on the cytokines of Th1/Th2 in murine model of asthma.


The murine model of asthma was induced by OVA. Different doses of baicalin were orally administered to the mice respectively. The spleen cells were cultured 3 days for the measurement of IFN-gamma, IL-4, IL-5 and IL-10 by ELISA. After 2 days of culture, the spleen cells were treated with Trizol for extraction of total RNA. The gene expressions of T-bet, GATA-3 and STAT-6 were analyzed by RT-PCR.


The treatment with baicalin obviously decreased the production of IL-4 and IL-5 and the gene expression of GATA-3, STAT-6, but increased the production of IL-10.


Baicalin may modulate the Th1/Th2 balance mainly by altering the gene expressions of GATA-3 and STAT-6 in vivo and increasing the production of IL-10.

[Indexed for MEDLINE]

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