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Radiology. 2010 Jan;254(1):277-84. doi: 10.1148/radiol.09082134.

Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy.

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1
Beckman Laser Institute, University of California, Irvine, CA 92612, USA.

Abstract

PURPOSE:

To develop a near-infrared spectroscopic method to identify breast cancer biomarkers and to retrospectively determine if benign and malignant breast lesions could be distinguished by using this method.

MATERIALS AND METHODS:

The study was HIPAA compliant and was approved by the university institutional review board. Written informed consent was obtained. By using self-referencing differential spectroscopy (SRDS) analysis, the existence of specific spectroscopic signatures of breast lesions on images acquired by using diffuse optical spectroscopy imaging in the wavelength range (650-1000 nm) was established. The SRDS method was tested in 60 subjects (mean age, 38 years; age range, 22-74 years). There were 17 patients with benign breast tumors and 22 patients with malignant breast tumors. There were 21 control subjects.

RESULTS:

Discrimination analysis helped separate malignant from benign tumors. A total of 40 lesions (22 malignant and 18 benign) were analyzed. Twenty were true-positive lesions, 17 were true-negative lesions, one was a false-positive lesion, and two were false-negative lesions (sensitivity, 91% [20 of 22]; specificity, 94% [17 of 18]; positive predictive value, 95% [20 of 21]; and negative predictive value, 89% [17 of 19]).

CONCLUSION:

The SRDS method revealed localized tumor biomarkers specific to pathologic state.

PMID:
20032159
PMCID:
PMC2797652
DOI:
10.1148/radiol.09082134
[Indexed for MEDLINE]
Free PMC Article
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