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Trends Microbiol. 2010 Feb;18(2):81-9. doi: 10.1016/j.tim.2009.12.001. Epub 2009 Dec 22.

Potential role for mucosally active vaccines against pneumococcal pneumonia.

Author information

1
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, P.O. Box 30096, Chichiri, Blantyre, Malawi. kjambo@liv.ac.uk

Abstract

Pneumococcal pneumonia is a life-threatening disease with high mortality and morbidity among children under 5 years of age, the elderly and immunocompromised individuals worldwide. Protection against pneumococcal pneumonia relies on successful regulation of colonisation in the nasopharynx and a brisk alveolar macrophage-mediated immune response in the lung. Therefore, enhancing pulmonary mucosal immunity (which includes a combination of innate, humoral and cell-mediated immunity) through mucosal vaccination might be the key to prevention of pneumococcal infection. Current challenges include a lack of information in humans on mucosal immunity against pneumococci and a lack of suitable adjuvants for new vaccines. Data from mouse models, however, suggest that mucosally active vaccines will enhance mucosal and systemic immunity for protection against pneumococcal infection.

PMID:
20031415
PMCID:
PMC2855428
DOI:
10.1016/j.tim.2009.12.001
[Indexed for MEDLINE]
Free PMC Article

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