Format

Send to

Choose Destination
Biol Chem. 2010 Feb-Mar;391(2-3):163-9. doi: 10.1515/BC.2010.021.

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity.

Author information

1
Mediterranean Institute of Life Sciences, Tumor Biology Program, Mestrovicevo setaliste bb, HR-21000 Split, Croatia.

Abstract

Localization, activity and lifespan of a protein are signaled by a small, 8 kDa protein, ubiquitin (Ub). Ub conjugation is a post-translational modification orchestrated by the sequential action of activating (E1), conjugating (E2), and ligating (E3) enzymes. Although a simple combination of an E2 and an E3 enzyme can be sufficient for an active complex, in other cases ubiquitination can occur in the context of large multimeric complexes with enhanced molecular abilities. Here, we review several Ub ligase complexes to highlight strategies governing conjugational specificity, the gained adaptability in substrate specificity, and modulatory flexibility encoded in regulatory components of these diverse multimers.

PMID:
20030582
DOI:
10.1515/BC.2010.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Sheridan PubFactory
Loading ...
Support Center