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Nat Rev Immunol. 2010 Jan;10(1):47-58. doi: 10.1038/nri2689.

Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates.

Author information

1
Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Abstract

The genetically tractable model organism Caenorhabditis elegans was first used to model bacterial virulence in vivo a decade ago. Since then, great strides have been made in identifying the host response pathways that are involved in its defence against infection. Strikingly, C. elegans seems to detect, and respond to, infection without the involvement of its homologue of Toll-like receptors, in contrast to the well-established role for these proteins in innate immunity in mammals. What, therefore, do we know about host defence mechanisms in C. elegans and what can they tell us about innate immunity in higher organisms?

PMID:
20029447
PMCID:
PMC2965059
DOI:
10.1038/nri2689
[Indexed for MEDLINE]
Free PMC Article

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