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Nat Rev Mol Cell Biol. 2010 Feb;11(2):138-48. doi: 10.1038/nrm2831. Epub 2009 Dec 23.

BRCA1 and its toolbox for the maintenance of genome integrity.

Author information

1
Department of Anatomy, The University of Hong Kong, Laboratory Block, 21 Sassoon Road, Hong Kong.

Abstract

The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response.

PMID:
20029420
PMCID:
PMC3899800
DOI:
10.1038/nrm2831
[Indexed for MEDLINE]
Free PMC Article

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