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J Comb Chem. 2010 Jan-Feb;12(1):195-9. doi: 10.1021/cc9001247.

Oriented synthesis and in vitro anticancer activity of biquinazoline-2,2'-diones.

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1
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, PR China.

Abstract

The synthesis of a series of biquinazoline-2,2'-diones starting from o-nitrobenzaldehydes, anilines, and triphosgene is presented. This general approach features a novel and easy way for access to the target products. The mechanistic course of the reaction suggests the involvement of reduction, coupling, and cyclization by one-pot. These compounds were also investigated in vitro for anticancer activity, and some were found to have good anticancer activity.

PMID:
20028094
DOI:
10.1021/cc9001247
[Indexed for MEDLINE]
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