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Nat Cell Biol. 2010 Jan;12(1):7-9. doi: 10.1038/ncb0110-7.

Myc and a Cdk2 senescence switch.

Abstract

Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

PMID:
20027199
DOI:
10.1038/ncb0110-7
[Indexed for MEDLINE]

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