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Obstet Gynecol. 2010 Jan;115(1):55-9. doi: 10.1097/AOG.0b013e3181c52132.

Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.

Author information

1
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-0001, USA. lemoore@salud.unm.edu

Abstract

OBJECTIVE:

To compare the efficacy of metformin with glyburide for glycemic control in gestational diabetes.

METHODS:

Patients with gestational diabetes who did not achieve glycemic control on diet were randomly assigned to metformin (n=75) or glyburide (n=74) as single agents. The primary outcome was glycemic control. Secondary outcomes were drug failure rate and neonatal and obstetric complications.

RESULTS:

In the patients who achieved adequate glycemic control, the mean fasting and 2-hour postprandial blood glucose levels were not statistically different between the two groups. However, 26 patients in the metformin group (34.7%) and 12 patients in the glyburide group (16.2%) did not achieve adequate glycemic control and required insulin therapy (P=.01).

CONCLUSION:

In this study, the failure rate of metformin was 2.1 times higher than the failure rate of glyburide when used in the management of gestational diabetes (95% confidence interval 1.2-3.9).

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, www.clinicaltrials.gov, NCT00965991.

LEVEL OF EVIDENCE:

I.

PMID:
20027034
DOI:
10.1097/AOG.0b013e3181c52132
[Indexed for MEDLINE]
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