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Semin Cell Dev Biol. 2010 Jul;21(5):472-8. doi: 10.1016/j.semcdb.2009.12.008. Epub 2009 Dec 21.

Life and death of a BiP substrate.

Author information

1
Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States.

Abstract

BiP is the mammalian endoplasmic reticulum (ER) Hsp70 orthologue that plays a major role in all functions of this organelle including the seemingly opposing functions of aiding the maturation of unfolded nascent proteins and identifying and targeting chronically unfolded proteins for degradation. The recent identification of mammalian BiP co-factors combined with delineation of the ER degradation machinery and data suggesting that the ER is subdivided into unique regions helps explain how these different functions can occur in the same organelle and raises some unresolved issues.

PMID:
20026282
PMCID:
PMC2883687
DOI:
10.1016/j.semcdb.2009.12.008
[Indexed for MEDLINE]
Free PMC Article

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