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FEBS Lett. 2010 Feb 19;584(4):707-12. doi: 10.1016/j.febslet.2009.12.019. Epub 2009 Dec 17.

Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway.

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Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.


A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-kappaB pathway. The combination of curcumin and IFNalpha exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents.

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