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Mol Microbiol. 2010 Feb;75(3):543-6. doi: 10.1111/j.1365-2958.2009.07022.x. Epub 2009 Dec 16.

Conformational flexibility of sigma(70) in anti-terminator loading.

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RNA Center, Case Western Reserve University, Cleveland, OH 44106-4973, USA.


In promoter DNA, the preferred distance of the -10 and -35 elements for interacting with RNA polymerase-bound sigma(70) is 17 bp. However, the Devi et al. paper in this issue of Molecular Microbiology demonstrates that when the C-terminal domain of sigma(70), including the 3.2 linker, is not attached to the core enzyme, distances between 0 and 3 bp can be accommodated. This attests to the great flexibility of the 3.2 linker. The particularly stable complex with the 2 bp separation may lend itself to structural studies of an early elongation complex containing sigma(70).

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