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J Am Chem Soc. 2010 Jan 20;132(2):470-1. doi: 10.1021/ja908250r.

InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.

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1
Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Abstract

We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700-900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging.

PMID:
20025222
PMCID:
PMC2862004
DOI:
10.1021/ja908250r
[Indexed for MEDLINE]
Free PMC Article

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