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Neurourol Urodyn. 2010;29(1):128-39. doi: 10.1002/nau.20837.

Neural control of the lower urinary tract: peripheral and spinal mechanisms.

Author information

1
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. lbirder@pitt.edu

Abstract

This review deals with individual components regulating the neural control of the urinary bladder. This article will focus on factors and processes involved in the two modes of operation of the bladder: storage and elimination. Topics included in this review include: (1) The urothelium and its roles in sensor and transducer functions including interactions with other cell types within the bladder wall ("sensory web"), (2) The location and properties of bladder afferents including factors involved in regulating afferent sensitization, (3) The neural control of the pelvic floor muscle and pharmacology of urethral and anal sphincters (focusing on monoamine pathways), (4) Efferent pathways to the urinary bladder, and (5) Abnormalities in bladder function including mechanisms underlying comorbid disorders associated with bladder pain syndrome and incontinence.

PMID:
20025024
PMCID:
PMC2910109
DOI:
10.1002/nau.20837
[Indexed for MEDLINE]
Free PMC Article

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