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ScientificWorldJournal. 2009 Dec 16;9:1423-37. doi: 10.1100/tsw.2009.154.

Visualizing vertebrate embryos with episcopic 3D imaging techniques.

Author information

1
Centre for Anatomy and Cell Biology, Medical University of Vienna, London.

Abstract

The creation of highly detailed, three-dimensional (3D) computer models is essential in order to understand the evolution and development of vertebrate embryos, and the pathogenesis of hereditary diseases. A still-increasing number of methods allow for generating digital volume data sets as the basis of virtual 3D computer models. This work aims to provide a brief overview about modern volume data-generation techniques, focusing on episcopic 3D imaging methods. The technical principles, advantages, and problems of episcopic 3D imaging are described. The strengths and weaknesses in its ability to visualize embryo anatomy and labeled gene product patterns, specifically, are discussed.

PMID:
20024516
PMCID:
PMC5823209
DOI:
10.1100/tsw.2009.154
[Indexed for MEDLINE]
Free PMC Article

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