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Chem Commun (Camb). 2010 Jan 7;46(1):76-8. doi: 10.1039/b915612g. Epub 2009 Oct 12.

Bioluminescent nanosensors for protease detection based upon gold nanoparticle-luciferase conjugates.

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1
Molecular Imaging Program at Stanford, Department of Radiology and Chemistry, Stanford University, Stanford, CA 94305-5484, USA.

Abstract

This communication reports the use of click chemistry to site-specifically conjugate bioluminescent Renilla luciferase proteins to gold nanoparticles (Au NPs) for sensing protease activity. The bioluminescent emission from luciferase was efficiently quenched by Au NPs, but significantly recovered after the proteolytic cleavage.

PMID:
20024298
PMCID:
PMC3930333
DOI:
10.1039/b915612g
[Indexed for MEDLINE]
Free PMC Article
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