Facile P,N-heterocycle synthesis via tandem aminomethylation-cyclization of H-phosphinate building blocks

Org Biomol Chem. 2010 Jan 7;8(1):267-73. doi: 10.1039/b917428a. Epub 2009 Nov 5.

Abstract

Various heterocycles containing phosphorus and nitrogen are easily synthesized from readily available H-phosphinate building blocks. Aminomethylation of these H-phosphinates is followed by in situ cyclization through substitution or cross-coupling to produce novel heterocycles in moderate to good yields.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cyclization
  • Heterocyclic Compounds / chemical synthesis*
  • Heterocyclic Compounds / chemistry
  • Molecular Structure
  • Nitrogen / chemistry
  • Phosphinic Acids / chemistry*
  • Phosphorus / chemistry

Substances

  • Heterocyclic Compounds
  • Phosphinic Acids
  • Phosphorus
  • Nitrogen