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Mol Biosyst. 2009 Dec;5(12):1512-26. doi: 10.1039/b908315d. Epub 2009 Oct 1.

Global signatures of protein and mRNA expression levels.

Author information

1
Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, TX, USA.

Abstract

Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

PMID:
20023718
PMCID:
PMC4089977
DOI:
10.1039/b908315d
[Indexed for MEDLINE]
Free PMC Article

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