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Nat Genet. 2010 Jan;42(1):24-6. doi: 10.1038/ng.506. Epub 2009 Dec 20.

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.

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1
Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany. e.mangold@uni-bonn.de

Abstract

We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).

PMID:
20023658
DOI:
10.1038/ng.506
[Indexed for MEDLINE]
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