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Nat Nanotechnol. 2010 Feb;5(2):121-6. doi: 10.1038/nnano.2009.450. Epub 2009 Dec 20.

Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami.

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Department of Nanoengineering, 9500 Gilman Drive M/C 0448, University of California San Diego, La Jolla, California 92093-0448, USA.


The development of nanoscale electronic and photonic devices will require a combination of the high throughput of lithographic patterning and the high resolution and chemical precision afforded by self-assembly. However, the incorporation of nanomaterials with dimensions of less than 10 nm into functional devices has been hindered by the disparity between their size and the 100 nm feature sizes that can be routinely generated by lithography. Biomolecules offer a bridge between the two size regimes, with sub-10 nm dimensions, synthetic flexibility and a capability for self-recognition. Here, we report the directed assembly of 5-nm gold particles into large-area, spatially ordered, two-dimensional arrays through the site-selective deposition of mesoscopic DNA origami onto lithographically patterned substrates and the precise binding of gold nanocrystals to each DNA structure. We show organization with registry both within an individual DNA template and between components on neighbouring DNA origami, expanding the generality of this method towards many types of patterns and sizes.

[Indexed for MEDLINE]

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