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Am J Obstet Gynecol. 2010 Jun;202(6):534.e1-6. doi: 10.1016/j.ajog.2009.10.857. Epub 2009 Dec 22.

Early menstrual characteristics associated with subsequent diagnosis of endometriosis.

Author information

1
Center for Military and Veterans' Health, The University of Queensland, Brisbane, Australia. s.treloar@uq.edu.au

Abstract

OBJECTIVE:

The aim of this study was to investigate the association between early menstrual characteristics, before symptom onset, and later diagnosis of endometriosis.

STUDY DESIGN:

This was a case-control study of 268 Australian women with surgically confirmed moderate-to-severe endometriosis (cases) and 244 women without endometriosis (controls). Early menstrual cycle characteristics, before age at symptom onset, were analyzed.

RESULTS:

Menarche after age 14 years was strongly and inversely associated with endometriosis (odds ratio, 0.3; 95% confidence interval, 0.1-0.6). A history of dysmenorrhea was associated with subsequent endometriosis (odds ratio, 2.6; 95% confidence interval, 1.1-6.2). Despite a suggestive trend, shorter menstrual cycle length was not associated with endometriosis. Duration of natural menstruation and heaviness of flow were not associated with subsequent risk of endometriosis; neither was the reported type of sanitary protection used nor history of sexual intercourse during menstruation.

CONCLUSION:

There is a decreased risk of endometriosis with late age at menarche and an increased risk in women who report an early history of dysmenorrhea.

PMID:
20022587
DOI:
10.1016/j.ajog.2009.10.857
[Indexed for MEDLINE]

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