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Int J Cardiol. 2010 Nov 19;145(2):316-317. doi: 10.1016/j.ijcard.2009.11.023.

Mutational analysis of the PITX2 and NKX2-5 genes in patients with idiopathic atrial fibrillation.

Author information

1
Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: leif-hendrik.boldt@charite.de.
2
Charité-Universitätsmedizin Berlin, Experimental and Clinical Research Center (ECRC), Lindenberger Weg 80, 13125 Berlin, Germany.
3
Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany.

Abstract

Atrial fibrillation (AF) is the most frequently encountered arrhythmia in clinical practice. In a subgroup of patients, AF is regarded as idiopathic when no signs of structural heart disease or other causes of the arrhythmia can be identified during conventional clinical work-up. Recent studies have demonstrated that AF has a substantial genetic basis in a number of cases. The entire coding sequences, including intron-exon boundaries, of the genes PITX2 and NKX2-5 were screened for genetic variants by means of initial polymerase chain reaction followed by DNA sequencing in 96 patients with idiopathic AF. Although we detected a number of variants, our candidate gene approach did not result in identification of mutations associated with AF in the coding regions of PITX2 or NKX2-5 in our well characterized AF cohort.

PMID:
20022124
DOI:
10.1016/j.ijcard.2009.11.023
[Indexed for MEDLINE]

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