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J Peripher Nerv Syst. 2009 Dec;14(4):257-67. doi: 10.1111/j.1529-8027.2009.00237.x.

Hyperlipidemia: a new therapeutic target for diabetic neuropathy.

Author information

1
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. andreav@umich.edu

Abstract

Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review, we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia (DRG) sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.

PMID:
20021567
PMCID:
PMC4239691
DOI:
10.1111/j.1529-8027.2009.00237.x
[Indexed for MEDLINE]
Free PMC Article

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