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Expert Opin Drug Saf. 2010 Jan;9(1):125-37. doi: 10.1517/14740330903485637.

Voriconazole therapeutic drug monitoring: focus on safety.

Author information

1
Universidade Federal do Rio Grande do Sul, Post Graduation Program in Pulmonary Sciences, Porto Alegre, Brazil.

Abstract

IMPORTANCE OF THE FIELD:

Voriconazole has been widely used for the treatment of invasive fungal diseases, particularly invasive aspergillosis. Drug-drug interactions are, however, the main drawback associated with voriconazole use, since this drug suffers from extensive hepatic metabolism.

AREAS COVERED IN THIS REVIEW:

This article reviews the current literature on voriconazole therapeutic drug monitoring, with a special focus on drug safety.

WHAT THE READER WILL GAIN:

An update on voriconazole metabolism, drug interactions, toxicity and the relation of these with voriconazole drug concentrations.

TAKE HOME MESSAGE:

Therapy with voriconazole may be better guided by measuring voriconazole concentrations in the plasma.

PMID:
20021293
DOI:
10.1517/14740330903485637
[Indexed for MEDLINE]

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