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Expert Opin Ther Pat. 2010 Jan;20(1):73-101. doi: 10.1517/13543770903490429.

Radiation countermeasure agents: an update.

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1
Université de Strasbourg, Centre Régional de Lutte contre le Cancer Paul Strauss, Laboratoire de Radiobiologie EA-3430, 3 rue de la Porte de l'Hôpital, F-67065 Strasbourg, France.

Abstract

IMPORTANCE OF THE FIELD:

Ionizing radiation (IR) can produce deleterious effects in living tissues, leading to significant morbidity and a potentially fatal illness affecting various organs dose-dependently. As people may be exposed to IR during cancer radiotherapy or as a result of a radiological/nuclear incident or act of terrorism, the danger of irradiation represents a serious public health problem. At present, however, this problem remains largely impervious to medical management. There is, therefore, a pressing need to develop safe and effective radiation countermeasure (RC) agents to prevent, mitigate or treat the harmful consequences of IR exposure.

AREAS COVERED IN THIS REVIEW:

Recent advances in the search for RC agents as reflected by the relevant patent literature of the past five years along with peer-reviewed publications are surveyed.

WHAT THE READER WILL GAIN:

A total of 43 patents, describing approximately 38 chemically diverse compounds with RC potential are analyzed. These include antioxidants capable of scavenging IR-induced free radicals, modulators of cell death signaling or cell cycle progression, cytokines or growth factors promoting tissue repair and inhibitors of inflammatory cytokines.

TAKE HOME MESSAGE:

Several of these RC candidates appear promising, including at least two that are undergoing evaluation for fast-track clinical development.

PMID:
20021286
DOI:
10.1517/13543770903490429
[Indexed for MEDLINE]
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