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Int J Hyperthermia. 2009 Dec;25(8):655-60. doi: 10.3109/02656730903039605.

A novel combination of mild electrical stimulation and hyperthermia: general concepts and applications.

Author information

1
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan. hirokai@gpo.kumamoto-u.ac.jp

Abstract

This review discusses the basic concepts, effects and applications of hyperthermia and mild electrical stimulation (MES) using low-intensity direct current. It also proposes a novel combinatorial use of MES and hyperthermia, and briefly outlines the rationale and the effects of MES and hyperthermia combination treatment on certain diseases (diabetes, hepatic ischaemia/reperfusion injury and gastric ulcer). The integrated modalities of MES and hyperthermia might find therapeutic applications to stress-induced diseases and intractable diseases of dysregulated signalling pathways.

PMID:
20021226
DOI:
10.3109/02656730903039605
[Indexed for MEDLINE]

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