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Am J Respir Crit Care Med. 2010 Mar 1;181(5):458-64. doi: 10.1164/rccm.200907-1022CR. Epub 2009 Dec 17.

Pulmonary alveolar proteinosis in workers at an indium processing facility.

Author information

1
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. cvx5@cdc.gov

Abstract

Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium in lung tissue specimens. One worker was tested for autoantibodies to granulocytemacrophage-colonystimulating factor (GM-CSF) and found to have an elevated level. These cases suggest that inhalational exposure to ITO causes pulmonary alveolar proteinosis, which may occur via an autoimmune mechanism.

PMID:
20019344
PMCID:
PMC3159086
DOI:
10.1164/rccm.200907-1022CR
[Indexed for MEDLINE]
Free PMC Article

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