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Bioorg Med Chem Lett. 2010 Feb 1;20(3):1278-83. doi: 10.1016/j.bmcl.2009.11.075. Epub 2009 Nov 20.

Diaryl piperidines as CB1 receptor antagonists.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. jack.scott@spcorp.com

Abstract

The syntheses and SAR investigations of novel CB(1) receptor antagonists based on a 1,2-diaryl piperidine core have been described. Optimization of this core afforded a compound with robust in vivo potency by reducing food intake in a mouse DIO model.

PMID:
20018510
DOI:
10.1016/j.bmcl.2009.11.075
[Indexed for MEDLINE]

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