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Opt Lett. 2009 Dec 15;34(24):3899-901. doi: 10.1364/OL.34.003899.

Intravital imaging of amyloid plaques in a transgenic mouse model using optical-resolution photoacoustic microscopy.

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Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.


We report optical-resolution photoacoustic microscopy (OR-PAM) for in vivo imaging of amyloid plaques in an Alzheimer's disease mouse model. Validation using conventional fluorescence microscopy and multiphoton microscopy shows that OR-PAM has sufficient sensitivity and spatial resolution to identify amyloid plaques in living brains. In addition, with dual-wavelength OR-PAM, the three-dimensional morphology of amyloid plaques and the surrounding microvasculature are imaged simultaneously through a cranial window without angiographic contrast agents. OR-PAM, capable of providing both exogenous molecular contrast and endogenous hemoglobin contrast, has the potential to serve as a new technology for in vivo microscopic observations of cerebral plaque deposits.

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