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Nat Immunol. 2010 Jan;11(1):21-7. doi: 10.1038/ni.1817. Epub 2009 Dec 17.

Mechanisms maintaining peripheral tolerance.

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1
Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. muell002@umn.edu

Abstract

The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide-MHC and threaten the health of the individual.

PMID:
20016506
DOI:
10.1038/ni.1817
[Indexed for MEDLINE]
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