Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Immunol. 2010 Mar;134(3):320-30. doi: 10.1016/j.clim.2009.11.006. Epub 2009 Dec 16.

Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3.

Author information

1
Department of Dermatology and Allergology, Philipps University Marburg, Germany. nagela@med.uni-marburg.de

Abstract

Pemphigus vulgaris (PV) is a severe autoimmune bullous skin disease and is primarily associated with IgG against desmoglein 3 (dsg3), a desmosomal adhesion protein. In light of the recent association of autoreactive T helper (Th) 2 cells with active PV, the present study sought to relate the occurrence of Th2-regulated dsg3-specific autoantibody subtypes, i.e. IgE and IgG4, in 93 well-characterized PV patients. Patients with acute onset PV (n=37) showed the highest concentrations of serum IgE and IgG4 autoantibodies, which were significantly lower in PV patients in remission (n=14). Furthermore, there was a strong correlation between dsg3-reactive IgE and IgG4 in acute onset, but not in chronic active (n=42) or remittent patients. Additionally, intercellular IgE deposits were detected in the epidermis of acute onset PV. Thus, dsg3-specific IgE and IgG4 autoantibodies are related to acute onset disease which provides additional support to the concept that PV is a Th2-driven autoimmune disorder.

PMID:
20015693
DOI:
10.1016/j.clim.2009.11.006
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center