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Atherosclerosis. 2010 May;210(1):274-7. doi: 10.1016/j.atherosclerosis.2009.11.005. Epub 2009 Nov 10.

An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction.

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1
Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy.

Abstract

BACKGROUND:

This study was designed to evaluate the biological significance of simultaneous changes in the circulating levels of osteoprotegerin (OPG) and TNF-related apoptosis inducing ligand (TRAIL) in patients with coronary artery disease (CAD), and, in particular, with acute myocardial infarction (AMI).

METHODS:

Total levels of OPG and TRAIL were measured by ELISA in patients with AMI (n=113), unstable angina (UA, n=21) and healthy controls (n=120).

RESULTS:

Since OPG was elevated during the acute phase (first 12-24-48h) after AMI and in patients with UA with respect to healthy controls, while TRAIL was decreased in acute AMI patients, CAD patients were characterized by an increased OPG/TRAIL ratio. Moreover, the OPG/TRAIL ratio was significantly (p<0.05) higher in the acute AMI patients who developed heart failure (HF) than in those who did not develop HF in the follow-up.

CONCLUSIONS:

An impaired OPG/TRAIL ratio after AMI is related to a higher risk of HF.

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