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Am J Drug Alcohol Abuse. 2009;35(6):434-8. doi: 10.3109/00952990903384332.

D-cycloserine and cocaine cue reactivity: preliminary findings.

Author information

1
Medical University of South Carolina, Department of Psychiatry, Clinical Neuroscience Division, 67 President Street, Charleston, SC 29425, USA. pricekl@musc.edu

Abstract

BACKGROUND:

D-cycloserine (DCS), a partial glutamate N-methyl-D-aspartic acid (NMDA) receptor agonist, enhances extinction of conditioned fear responding in rodents and facilitates exposure-based learning in humans with anxiety disorders.

OBJECTIVES:

This preliminary study investigates DCS pretreatment on response to cocaine cues in cocaine-dependent subjects.

METHODS:

Ten cocaine-dependent subjects were randomly assigned to receive either 50 mg DCS or matching placebo two hours before each of two 1-hour cocaine cue exposure sessions one day apart. HR and craving ratings were obtained before and during cue exposure sessions.

RESULTS:

There was a trend towards increased craving to cocaine cues in cocaine-dependent individuals after administration of DCS.

CONCLUSIONS:

The administration of DCS prior to cue exposure sessions may facilitate response activation.

SCIENTIFIC SIGNIFICANCE:

While facilitation of extinction-based learning by DCS may have therapeutic potential for cocaine dependence, this drug may exhibit a different profile in cocaine-dependent individuals as compared to those with anxiety disorders.

PMID:
20014913
PMCID:
PMC2805418
DOI:
10.3109/00952990903384332
[Indexed for MEDLINE]
Free PMC Article

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